The Koti Laboratory is located at the Sinclair Cancer Research Institute (SCRI), Queen's University. The SCRI is constituted by three divisions; Cancer Biology and Genetics, Cancer Care and Epidemiology and Cancer Clinical Trials.
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Dr. Koti is a Veterinarian with PhD in Immunology. She is currently an Associate Professor in the Departments of Biomedical and Molecular Sciences and Obstetrics and Gynaecology at Queen’s University. She is also cross-appointed to the Department of Urology and is a member of the Division of Cancer Biology and Genetics at the SCRI.
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Research Overview
Cancer Immunology
Our research focuses on investigating the interactions between host immune physiology and cancer cell intrinsic features that determine response to immuno-modulatory treatments.
Research Objectives
Using bladder cancer patient derived specimens, cell lines, and immunocompetent mouse models to study the tumour-immune interactions, the primary goals of our research program are:
01
Sex Differences, Aging Immune System, and Cancer
To advance our understanding on the influence of sex differences and aging in anti-tumour immunity and treatment outcomes.
02
Tumour Immune Microenvironment
To delineate the role of cancer cell intrinsic genetic events in the evolution of variable pre-treatment states of the tumour immune microenvironment.
03
Immuno-modulary Therapies
To develop combination immune priming approaches to enhance sensitivity to immuno-modulatory therapies in cancer.
Research Funded By
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Our Facilities
Our laboratory at the Sinclair Cancer Research Institute, Queen's University, integrates advanced techniques that enable a comprehensive approach to study several aspects of anti-tumor immunity. The laboratory is equipped with a tissue culture facility, Cytoflex-S flow cytometer, RoboSep-S automated cell isolation system, AutoMacs tissue dissocator in addition to equipment necessary for routine molecular biology experiments. The collaborative environment at the SCRI also benefits from seamless access to broader resources at the departmental core facilities that house advanced cutting-edge tools of research on cancer immunology. Pre-clinical studies using aging mouse models are conducted in the state-of-the-art animal facility located in close proximity to the laboratory.
